Stanley Kubrick

Regissör

Keir Dullea

Dr. David Bowman

Gary Lockwood

Dr. Frank Poole

William Sylvester

Dr. Heywood Floyd

Douglas Rain

HAL 9000 (röst)

Daniel Richter

Moonwatcher

Leonard Rossiter

Dr. Andrei Smyslov

Margaret Tyzack

Elena

Robert Beatty

Dr. Ralph Halvorsen

Ed Bishop

Aries-1B Lunar Shuttle Captain

Glenn Beck

Astronaut

Alan Gifford

Poole's Father

Ann Gillis

Poole's Mother

Edwina Carroll

Aries-1B Stewardess

Penny Brahms

Stewardess

David Charkham

Ape

Maggie London

Hostess in Elevator (okrediterad)

Chela Matthison

Receptionist (okrediterad)

Vivian Kubrick

Floyd's Daughter (okrediterad)

Kenneth Kendall

BBC-12 Announcer (okrediterad)

Kevin Scott

Miller (okrediterad)

Burnell Tucker

TMA-1 Site Photographer (okrediterad)

John Swindells

TMA-1 Site Technician #1 (okrediterad)

Stanley Kubrick

Astronaut Breathing (röst) (okrediterad)

Sean Sullivan

Dr. Roy Michaels

Frank W. Miller

Mission Controller (röst)

Bill Weston

Astronaut

Heather Downham

Stewardess

Mike Lovell

Astronaut

John Ashley

Ape

Jimmy Bell

Ape

Keith Denny

Ape

Jonathan Daw

Ape

Péter Delmár

Ape

Terry Duggan

Ape Attacked by Leopard

David Fleetwood

Ape

Danny Grover

Ape

Brian Hawley

Ape

David Hines

Ape

Anthony Jackson

Ape

John Jordan

Ape

Scott MacKee

Ape

Laurence Marchant

Ape

Darryl Paes

Ape

Joe Refalo

Ape

Andy Wallace

Ape

Bob Wilyman

Ape

Richard Woods

Ape Killed by Moon-Watcher

Judy Keirn

röst Print Identification Girl (okrediterad)

Martin Amor

Interviewer (okrediterad)

S. Newton Anderson

Young Man (okrediterad)

Sheraton Blount

(okrediterad)

Ann Bormann

(okrediterad)

Julie Croft

(okrediterad)

Penny Francis

(okrediterad)

Marcella Markham

(okrediterad)

Irena Marr

Russian Scientist (okrediterad)

Krystyna Marr

Russian Scientist (okrediterad)

Kim Neil

(okrediterad)

Jane Pearl

(okrediterad)

Penny Pearl

(okrediterad)

John Clifford

TMA-1 Site Technician #2 (okrediterad)

Harry Fielder

Moonwalker (okrediterad)